How HEMGENIX® Works
WHAT IS HEMGENIX®?
People with haemophilia B are born with a version of the F9 gene that does not work properly.1 This means that the liver cannot make enough of its own FIX.1
HEMGENIX® is a gene therapy specifically designed to target haemophilia B.2 It aims to give your liver the instructions to make its own working FIX.1,3
HEMGENIX® offers bleed protection that can last for years after a single infusion.3 The goal of HEMGENIX® is to offer protection from bleeds, without the need for regular FIX infusions.1,3
HOW DOES HEMGENIX® WORK?
HEMGENIX® works by giving you a working version of the F9 gene. The gene is put inside a virus, which carries it to the liver.1,3
The virus used for gene therapy is inactivated. This means that it cannot spread in the body and does not cause illness in humans.1,3
Once the gene is delivered, the liver can start making its own FIX.3
The gene should stay in the liver cells, without becoming part of your DNA.3
The goal of HEMGENIX® is to provide protection from bleeds, without the need for regular FIX infusions.1,3
FIX, factor IX.
References
1. Nathwani AC. Gene therapy for hemophilia. Hematology Am Soc Hematol Educ Program. 2019;2019(1):1–8. 2. HEMGENIX® (etranacogene dezaparvovec). Summary of product characteristics. 3. Nathwani AC. Gene therapy for hemophilia. Hematology Am Soc Hematol Educ Program. 2022;2022(1):569–578.
Reporting side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme. By reporting side effects, you can help provide more information on the safety of this medicine.
